Mechanics of soft and living interfaces
We develop mathematical and computational models to understand the mechanics of biological interfaces, cells and tissues, with the goal of making this understanding quantitative and mechanistic, of rationally manipulating active living materials and of engineering new bionic and bioinspired materials.
The group on Mechanics of soft and living interfaces belongs to the Research program on Cell and tissue mechanobiology @ LaCàN at the Universitat Politècnica de Catalunya-BarcelonaTech. It is lead by Prof. Marino Arroyo, professor at UPC also an associated researcher at CIMNE and IBEC.
more about our research...
Biological interfaces across scales, including biomembranes, the cell cortex, or epithelial sheets, are unique multifunctional materials that control key structural and mechanical functions of cells and tissues, including their shape, mechanical properties, and locomotion. At scales below 10s of microns, elasticity, hydrodynamics and chemistry become intertwined and these systems are permanently driven out of equilibrium by biological activity. Furthermore, large geometric transformations and molecular crowding lead to strong nonlinearity. Our goal is to develop theoretical models and computational methods to quantitatively understand the mechanobiology of these interfaces, in tight interaction with experiments. We hope to answer fundamental scientific questions and to transpose the underlying engineering principles of these biological interfaces into to new artificial materials.
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system, F. Lolo, N Walani et al, Nature Cell Biology, 2022.
Patterning of membrane adhesion under hydraulic stress, C Dinet, A Torres-Sánchez, M Arroyo, M Staykova, bioRxiv, 2023.
Slack-taut transition and emergent stiffness in bioinspired entangled filament networks, M. Pensalfini, T. Golde, X. Trepat, M. Arroyo, arXiv, 2022.
Mapping mechanical stress in curved epithelia of designed size and shape, AMarín-Llauradó, S Kale, A Ouzeri, R Sunyer, A Torres-Sánchez, E Latorre, M Gómez-González, P Roca-Cusachs, M Arroyo, X Trepat, bioRxiv, 2022.
Peeling dynamics of fluid membranes bridged by molecular bonds: moving or breaking, D. Kaurin, P.K Bal, M. Arroyo, Journal of the Royal Society Interface, 2022.
A theory for the flow of chemically-responsive polymer solutions: equilibrium and shear-induced phase separation, M de Corato, M. Arroyo, Journal of Rheology, 2022.
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration, C Pérez-González, G Ceada, F Greco, M Matejčić, M Gómez-González, N Castro, A Menendez, S Kale, D Krndija, AG Clark, V Ram Gannavarapu, A Álvarez-Varela, P Roca-Cusachs, E Batlle, D Matic Vignjevic, M Arroyo & X Trepat, Nature Cell Biology, 2021
Dynamic mechanochemical feedback between curved membranes and BAR protein self-organization, A.L. Le Roux, C. Tozzi, N. Walani, X. Quiroga, D. Zalvidea, X. Trepat, M. Staykova, M. Arroyo, P. Roca-Cusachs, Nature Comms, 2021
A theory of ordering of elongated and curved proteins on membranes driven by density and curvature, C. Tozzi, N. Walani, A.L. Le Roux, P. Roca-Cusachs, M. Arroyo, Soft Matter, 2021
A physical mechanism of TANGO1-mediated bulky cargo export, I. Raote, M. Chabanon, N. Walani, M. Arroyo, M.F. García-Parajo, V. Malhorta, F. Campelo, eLife, 2020.
Spontaneous polarization and locomotion of an active particle with surface-mobile enzymes, M. De Corato, I. Pagonabarraga, L.K.E.A. Abdelmohsen, S. Sánchez, M. Arroyo, Physical Review Fluids, 2020.
Measuring mechanical stress in living tissues, M. Gómez-González, E. Latorre, M. Arroyo, X. Trepat, Nature Reviews Physics, 2020.
Self-Propulsion of Active Colloids via Ion Release: Theory and Experiments, M. De Corato, X. Arqué, T. Patiño, M. Arroyo, S. Sánchez, I. Pagonabarraga, Physical Review Letters, 2020.
The 2020 motile active matter roadmap, G. Gompper et al., Journal of Physics: Condensed Matter, 2020.
Approximation of tensor fields on surfaces of arbitrary topology based on local Monge parametrizations, A. Torres-Sánchez, D. Santos-Oliván, M. Arroyo, J Computational Physics, 2019.
Out-of-equilibrium mechanochemistry and self-organization of fluid membranes interacting with curved proteins, C. Tozzi, N. Walani, M. Arroyo, New J Phys, 2019
The plasma membrane as a mechanochemical transducer, A.-L. Le Roux, X. Quiroga, N. Walani, M. Arroyo, P. Roca-Cusachs, Phil. Trans. R. Soc. B, 2019
Surface tension controls the hydraulic fracture of adhesive interfaces bridged by molecular bonds, D. Kaurin, M. Arroyo, Physical Review Letters, 2019.
Morphable structures from unicellular organisms with active, shape-shifting envelopes: Variations on a theme by Gauss, G. Cicconofri, M. Arroyo, G. Noselli, A. DeSimone, Int J Non-Linear Mechanics, 2019
Mechanics of axisymmetric sheets of interlocking and slidable rods, D. Riccobelli, G. Noselli M. Arroyo, A. DeSimone, J Mech Phys Solids, 2020.
Combined molecular/continuum modeling reveals the role of friction during fast unfolding of coiled-coil proteins, A. Torres-Sánchez, J.M. Vanegas, P.K. Purohit, M. Arroyo*, Soft Matter, 2019
Modelling fluid deformable surfaces with an emphasis on biological interfaces, A. Torres-Sánchez, D. Millán, M. Arroyo*, Journal of Fluid Mechanics, 2019
Swimming Euglena respond to confinement with a behavioural change enabling effective crawling, G. Noselli, A. Beran, M. Arroyo*, A. DeSimone*, Nature Physics, 2019
Smart helical structures inspired by the pellicle of euglenids, G. Noselli, M. Arroyo, A. DeSimone, Journal of the Mechanics and Physics of Solids, 2019
Active superelasticity in three-dimensional epithelia of controlled shape, E. Latorre, S. Kale, L. Casares, M. Gómez-González, M. Uroz, L. Valon, R.V. Nair, E. Garreta, N. Montserrat, A. del Campo, B. Ladoux, M. Arroyo*, X. Trepat*, Nature, 2018
see commentary here.
A variational model of fracture for tearing brittle thin sheets, B. Li, D. Millán, A. Sanchez-Torres, B. Roman, M. Arroyo, Journal of the Mechanics and Physics of Solids, 2018
Hydraulic fracturing in cells and tissues: fracking meets cell biology, M. Arroyo, X. Trepat, Current Opinion in Cell Biology, 2017
Onsager’s Variational Principle in Soft Matter: Introduction and Application to the Dynamics of Adsorption of Proteins onto Fluid Membranes, M. Arroyo, N. Walani, A. Torres-Sánchez and D. Kaurin, Chapter in the book “The role of mechanics in the study of lipid bilayers”, CISM, 2017
Maximum-entropy meshfree coordinates in computational mechanics, M. Arroyo, Chapter in the book “Generalized Barycentric Coordinates in Computer Graphics and Computational Mechanics”, CRC Press, 2017
Geometric derivation of the microscopic stress: A covariant central force decomposition, A. Sanchez-Torres, J.M. Vanegas, M. Arroyo, Journal of the Mechanics and Physics of Solids, 2016
Examining the Mechanical Equilibrium of Microscopic Stresses in Molecular Simulations, A.Torres-Sánchez, J.M. Vanegas, M. Arroyo, Physical Review Letters, 2015 COMPUTER CODE
Charting molecular free-energy landscapes with an atlas of collective variables, B. Hashemian, D. Millán, M. Arroyo, Journal of Chemical Physics, 2016
Hydraulic fracture and toughening of a brittle layer bonded to a hydrogel, A.Lucantonio, G. Noselli, X. Trepat, A. DeSimone, M. Arroyo, Physical Review Letters, 2015
See commentary in Physics here
Coexistence of wrinkles and blisters in supported graphene, K. Zhang, M. Arroyo, Extreme Mechanics Letters, 2016
Hydraulic fracture during epithelial stretching, L. Casares, R. Vincent, D. Zalvidea, N. Campillo, D. Navajas, M. Arroyo*, X. Trepat*, Nature Materials, 2015
Physical principles of membrane remodelling during cell mechanoadaptation, A.J. Kosmalska, et al, Nature Communications, 2015